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使用計算機控制的刺激量化機械敏感性

評估超閾值機械敏感性

測量機械閾值而不進行多次測試

范圍：0.5N - 10N

卓越的分辨率（至0.3mN）

以任何方向運作

***小化軸外力

提供的提示范圍（0.5,0.8,1,1.5,2,3毫米直徑）

應用區域在整個力范圍內保持不變

參考文獻：

Kumar, Siddarth. et al. “Viscoelastic characterization of the primate finger pad in vivo by microstep indentation and three-dimensional finite element models for tactile sensation studies .” Journal of Biomechanical Engineering 137.6 (2015): 061002.

Qi, Huixin et al. “Cortical neuron response properties are related to lesion extent and behavioral recovery after sensory loss from spinal cord injury in monkeys.” The Journal of Neuroscience 34.12 (2014): 4345-4363.

Dieudonné, Alexandre et al. “Encoding properties of the mechanosensory neurons in the Johnston's organ of the hawk moth, Manduca sexta.” The Journal of Experimental Biology 217.17 (2014): 3045-3056.

Milenkovic, Nevena et al. “A somatosensory circuit for cooling perception in mice.” Nature Neuroscience17.11 (2014): 1560-1566.

Reed, Jamie L. et al. “Effects of spatiotemporal stimulus properties on spike timing correlations in owl monkey primary somatosensory cortex.” Journal of Neurophysiology 108.12 (2012): 3353-3369.

Jankowski, Michael P. et al. “Dynamic changes in heat transducing channel TRPV1 expression regulate mechanically insensitive, heat sensitive C-fiber recruitment after axotomy and regeneration.” The Journal of Neuroscience 32.49 (2012): 17869-17873.

Molliver, Derek C. et al. “The ADP receptor P2Y1 is necessary for normal thermal sensitivity in cutaneous polymodal nociceptors.” Molecular Pain 7.1 (2011): 13.

Ge, Weiqing, and Partap S. Khalsa. “Encoding of compressive stress during indentation by group III and IV muscle mechano-nociceptors in rat gracilis muscle.” Journal of Neurophysiology 89.2 (2003): 785-792.

Bove, Geoffrey M., Daniel R. Robichaud, and Peter Grigg. “Three-dimensional load analysis of indentation stimulators.” Journal of Neuroscience Methods 123.1 (2003): 23-30.

Khalsa, Partap S., Ce Zhang, and Yi-Xian Qin. “Encoding of location and intensity of noxious indentation into rat skin by spatial populations of cutaneous mechano-nociceptors.” Journal of Neurophysiology 83.5 (2000): 3049-3061.

300C-I機械刺激器是***種自動電子von Frey設備，具有在單個應用點測量和控制力和長度的附加功能。300C-I采用手持式von Frey燈絲或其他手持式機械刺激器來消除力量的變化和尷尬。我們的計算機控制機械刺激器消除了與von Frey細絲和其他電子von Frey系統相關的不可避免的手震顫。這消除了力應用中的相關變化。

Aurora Scientific的機械刺激器無需多次測試即可確定閾值，從而提高了吞吐量。力的施加和刺激的時間是***致和精確的，從而消除了與手持設備相關的可變性。

機械刺激器能夠在預設的時間段內施加恒定的力，并具有以預定速率調節力的附加功能。刺激可以以長度或力的任何組合應用，并且可以遵循任意的力或距離施加曲線，因此施力不限于簡單的力斜坡。

恒定和可重復力的傳遞確保實驗，受試者和研究之間保持***致性，從而減少數據中可避免的錯誤并提高您的發現質量。